CLINICAL TESTS BY THE UNIVERSITY OF FERRARA
TEWL Test

The Transepidermal Water Loss (TEWL) test is a clinical test that measures trans-cutaneous water loss before and after the use of a skincare product through an objective analysis. TEWL is a physiological phenomenon that consists of the continuous diffusion and evaporation of water through the outer layers of the skin. The lower the TEWL, the better the state of the skin barrier and the greater the well-being of your skin.
The University of Ferrara conducted the TEWL test on two of our products: Face Cleanser and Face Cream. The results of the instrumental evaluations were surprisingly strong, in just 15 days. Using the Face Cleanser improved TEWL by 32%, while using the Face Cream improved TEWL by 28%. In other words, used individually, our products are able to increase your skin well-being by 32% and 28% respectively.

Average TEWL (in g/m2/h) before (T0) and after (T15) using Aeqium Face Cleanser

Average TEWL (in g/m2/h) before (T0) and after (T15) using Aeqium Face Cream

Evaluation period: July 2020. Sample: 12 + 12 female and male subjects over the age of 18 years. Procedure: Each product is applied 2 times per day for a period of 15 days. Instrumental evaluation is performed before treatment (T0) and after 15 days of product use (T15).

Lenitive Test

The Lenitive Test is a clinical test that evaluates the soothing and de-reddening power of a skincare product through an objective and subjective analysis. To induce redness and irritative sensations, volunteers are applied a skin irritating solution in accordance with the Helsinki protocol. The evaluation is carried out initially on the non-reddened skin and after the application of the product on the reddened area at 15-minute intervals (T0, T5, T15, T30, T45).
The University of Ferrara has conducted the soothing test on our Body Cream, finding extraordinary soothing and anti-reddening capabilities. The Body Cream is in fact able to significantly soothe the irritating sensations of the skin in just 15 minutes from their onset and even the redness, evident in the irritated area, is attenuated.

Average Irritation Index (0, 5, 15, 30, 45 minutes after applying the Body Cream)

Legend:
0 = No irritation, 1 = Mild irritation, 2 = Moderate irritation, 3 = Severe irritation.

Evaluation period: October 2020. Sample: 10 female and male subjects over 18 years of age. Procedure: For objective evaluation, in accordance with the Helsinki protocol, redness was detected after application of a 0.1% Benzyl Nicotinate solution. For the subjective evaluation, volunteers were asked to give feedback on skin parameters related to itching, burning and stinging sensations. The instrumental evaluation is carried out initially on non-reddened skin to define the white (T00) and after the application of the product on the reddened area at 15-minute intervals (T0, T5, T15, T30, T45).

Compound Test

The Compound Test is a clinical test with which the University of Ferrara has measured the benefits of a joint use of Aeqium’s dermocosmetics and nutraceuticals in the long term. The test was carried out on two dermocosmetics, Face Cleanser and Face Cream, and one nutraceutical, Boost-Purify. After just 60 days of use, the results of the instrumental evaluations reveal a considerable improvement in hydration (+44%). Microscopy images also show a visible improvement in the state of the skin barrier (increase in skin elasticity, reduction of wrinkles and other imperfections).

Average state of hydration (in degrees of surface humidity) before (T0) and after (T60) the joint use of three Aeqium products

Before (T0)

After (T60)

Evaluation period: October-November 2020. Sample: 20 female and male subjects aged 42-70 years. Procedure: Dermocosmetics are applied twice a day for a period of 60 days. The treatment is complemented with the use of two specific supplements to be taken one in the morning (Boost-Purify Morning) and one in the evening (Boost-Purify Evening). Instrumental evaluation is performed before treatment (T0) and after 60 days of product use  (T60).

Patch Test on sensitive skin

The Patch test is a clinical test that is performed to evaluate the skin compatibility with a skincare product, defined as the absence of irritation following the application of the product. The product is applied to the skin in a single dose through the use of a patch in order to exaggerate the exposure compared to the real-life use.

The University of Ferrara conducted the patch test for our Face Cream on a sample of volunteers with sensitive skin. The product obtained an average irritation index of 0.00, both after 24 hours and after 48 hours from the application of the product. The Face Cream can therefore be classified as Non-Irritating on sensitive skin and, therefore, suitable for all skin types.

Evaluation period: December 2020. Sample: 20 female and male subjects with sensitive skin aged between 22 and 60 years. Procedure: The sample is laid in a special patch and is, then, applied on the back of the volunteer. The product is left there for 24 hours. Evaluation of reactions is done 30 minutes and 24 hours after removal of the patch.